IL33 and CRMP1

Data Source:
HPRD (two hybrid)

		IL33	CRMP1
Description		interleukin 33	collapsin response mediator protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Transport Vesicle Intracellular Membrane-bounded Organelle	Nucleus Centrosome Spindle Cytosol Growth Cone Midbody Perikaryon
	Molecular Function	Interleukin-33 Receptor Binding Cytokine Activity Protein Binding	Dihydropyrimidinase Activity Protein Binding Filamin Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Microglial Cell Activation Involved In Immune Response Negative Regulation Of Immunoglobulin Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Cellular Defense Response Positive Regulation Of Gene Expression Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Microglial Cell Proliferation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Proliferation Positive Regulation Of Neuroinflammatory Response Positive Regulation Of CD86 Production Positive Regulation Of CD80 Production	Microtubule Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance Negative Regulation Of Neuron Projection Development Negative Regulation Of Actin Filament Binding
Pathways		PIP3 activates AKT signaling Ub-specific processing proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling	CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 21804549 31361310 31959851 30929738 20860503 27182965 32296059 31619474 29785011 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 24241537 29273806) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Chronic rhinosinusitis ( 30643255) Eczema ( 31361310) Endometriosis ( 23472165) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Periodontal microbiota ( 22699663) Self-reported allergy ( 23817569) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Small cell lung carcinoma ( 28604730)	Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: CASP1 CRMP1 H2AC18 H2BC21 IL1RL1	80 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24
Entrez ID		90865	1400
HPRD ID		12275	03913
Ensembl ID		ENSG00000137033	ENSG00000072832
Uniprot IDs		O95760	B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1
PDB IDs		2KLL 4KC3	4B3Z
Enriched GO Terms of Interacting Partners?
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