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IL33 and CASP1
Data Source:
BioGRID
(enzymatic study)
IL33
CASP1
Description
interleukin 33
caspase 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Transport Vesicle
Intracellular Membrane-bounded Organelle
Extracellular Region
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Protein-containing Complex
IPAF Inflammasome Complex
NLRP1 Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Protease Inhibitor Complex
Molecular Function
Interleukin-33 Receptor Binding
Cytokine Activity
Protein Binding
Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Kinase Binding
Identical Protein Binding
CARD Domain Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cytokine Production
Microglial Cell Activation Involved In Immune Response
Negative Regulation Of Immunoglobulin Production
Positive Regulation Of Immunoglobulin Production
Negative Regulation Of Leukocyte Migration
Negative Regulation Of T-helper 1 Type Immune Response
Positive Regulation Of Type 2 Immune Response
Positive Regulation Of Cellular Defense Response
Positive Regulation Of Gene Expression
Protein Deubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Macrophage Activation
Positive Regulation Of MHC Class I Biosynthetic Process
Positive Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Defense Response To Virus
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Microglial Cell Proliferation
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Macrophage Proliferation
Positive Regulation Of Neuroinflammatory Response
Positive Regulation Of CD86 Production
Positive Regulation Of CD80 Production
Response To Hypoxia
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Regulation Of Autophagy
Protein Autoprocessing
Cytokine-mediated Signaling Pathway
Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Alpha Production
Positive Regulation Of Interleukin-1 Beta Production
Response To ATP
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Inflammatory Response
Mitochondrial Depolarization
Membrane Hyperpolarization
Pyroptosis
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Substance
Cellular Response To Cytokine Stimulus
Cellular Response To Interferon-gamma
Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Programmed Necrotic Cell Death
Signaling Receptor Ligand Precursor Processing
Toxin Transport
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways
PIP3 activates AKT signaling
Ub-specific processing proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling
NOD1/2 Signaling Pathway
Interleukin-1 processing
TP53 Regulates Transcription of Caspase Activators and Caspases
The NLRP3 inflammasome
The AIM2 inflammasome
The IPAF inflammasome
Interleukin-37 signaling
Purinergic signaling in leishmaniasis infection
Drugs
Acetylsalicylic acid
Minocycline
Pralnacasan
LAX-101
Emricasan
VX-765
1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
Z-Val-Ala-Asp fluoromethyl ketone
3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
30013184
31361310
)
Allergy (
27182965
)
Asthma (
21804549
31361310
31959851
30929738
20860503
27182965
32296059
31619474
29785011
29273806
)
Asthma (adult onset) (
31036433
30929738
)
Asthma (childhood onset) (
31036433
30929738
24241537
29273806
)
Asthma (moderate or severe) (
30552067
)
Asthma (time to onset) (
27130862
)
Asthma and hay fever (
24388013
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Chronic rhinosinusitis (
30643255
)
Eczema (
31361310
)
Endometriosis (
23472165
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Medication use (antihistamines for systemic use) (
31015401
)
Medication use (glucocorticoids) (
31015401
)
Nasal polyps (
30643255
)
Neutrophil percentage of white cells (
32888494
)
Periodontal microbiota (
22699663
)
Self-reported allergy (
23817569
)
Serum metabolite levels (
31636271
)
Serum metabolite levels (CMS) (
31636271
)
Small cell lung carcinoma (
28604730
)
Hip circumference adjusted for BMI (
28552196
)
Interacting Genes
5 interacting genes:
CASP1
CRMP1
H2AC18
H2BC21
IL1RL1
42 interacting genes:
AR
ATN1
ATXN3
BCAP31
BCL2L1
BID
CARD16
CARD17
CARD8
CASP10
CASP14
CASP8
CAST
CDK11B
EGFR
FGF2
HTT
IL18
IL1A
IL1B
IL33
IL37
LMNA
MAPT
NEDD4
NFE2L2
NLRC4
NLRP1
NOD1
PAK1
PARP1
PLA2G4A
PLA2G4B
PRKN
PSEN1
PSEN2
PYCARD
RIPK2
SERPINB9
TFAP2A
TIRAP
VAC14
Entrez ID
90865
834
HPRD ID
12275
00977
Ensembl ID
ENSG00000137033
ENSG00000137752
Uniprot IDs
O95760
A8K249
A8K257
P29466
PDB IDs
2KLL
4KC3
1BMQ
1IBC
1ICE
1RWK
1RWM
1RWN
1RWO
1RWP
1RWV
1RWW
1RWX
1SC1
1SC3
1SC4
2FQQ
2H48
2H4W
2H4Y
2H51
2H54
2HBQ
2HBR
2HBY
2HBZ
3D6F
3D6H
3D6M
3E4C
3NS7
5FNA
5MMV
5MTK
6BZ9
6F6R
6KN0
6PZP
6VIE
Enriched GO Terms of Interacting Partners
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