KNSTRN and PPL

Data Source:
BioGRID (two hybrid)

		KNSTRN	PPL
Description		kinetochore localized astrin (SPAG5) binding protein	periplakin
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Ruffle Nucleus Cytoplasm Plasma Membrane Centriolar Satellite Microtubule Plus-end Mitotic Spindle	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity Microtubule Plus-end Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule Cytoskeleton Organization Spindle Organization Chromosome Segregation Cell Migration Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Epidermal Growth Factor Stimulus	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways			Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Heschl's gyrus morphology ( 25130324) Malaria ( 31844061)	Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)
Interacting Genes		17 interacting genes: ABI2 BEX2 CHMP1B CLU HSPB1 IFT20 MAPK6 MAPRE1 MAPRE3 MPHOSPH6 NUPR1 OIP5 PALS2 PPL SGF29 WASHC3 ZDHHC17	43 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		90417	5493
HPRD ID		12669	04187
Ensembl ID		ENSG00000128944	ENSG00000118898
Uniprot IDs		Q9Y448	O60437
PDB IDs			4Q28
Enriched GO Terms of Interacting Partners?
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