PPL and MRPL28

Data Source:
BioGRID (two hybrid)

		PPL	MRPL28
Description		periplakin	mitochondrial ribosomal protein L28
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GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit Cytosol
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)	Body mass index ( 26426971) Heel bone mineral density ( 28869591) Refractive error ( 32231278)
Interacting Genes		43 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	28 interacting genes: ABI2 APP BANP CDCA7L CDR2 ENKD1 FAM9B HMBOX1 HSPB1 HTR2A IKZF3 LARP1B LENG1 LRRK2 NFKBID OXA1L PPL SCNM1 TEF TRAF3IP2 TRAF4 TSHZ3 TSSK3 TUBB3 UPP2 USP2 USP20 ZNF655
Entrez ID		5493	10573
HPRD ID		04187	06889
Ensembl ID		ENSG00000118898	ENSG00000086504
Uniprot IDs		O60437	Q13084
PDB IDs		4Q28	3J7Y 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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