PPL and UPRT

Data Source:
BioGRID (two hybrid)

		PPL	UPRT
Description		periplakin	uracil phosphoribosyltransferase homolog
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Protein Binding GTP Binding
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	UMP Biosynthetic Process Female Pregnancy Lactation Nucleoside Metabolic Process Phosphorylation Response To Insulin
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)
Interacting Genes		43 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	9 interacting genes: COMMD1 ERH GGA3 HSF2BP KAT5 NPM3 POLR2G PPL PYROXD1
Entrez ID		5493	139596
HPRD ID		04187	06640
Ensembl ID		ENSG00000118898	ENSG00000094841
Uniprot IDs		O60437	A0A0A0MRR5 A8KAF9 Q96BW1
PDB IDs		4Q28
Enriched GO Terms of Interacting Partners?
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