KNSTRN and MPHOSPH6

Data Source:
HPRD (two hybrid)

		KNSTRN	MPHOSPH6
Description		kinetochore localized astrin (SPAG5) binding protein	M-phase phosphoprotein 6
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Ruffle Nucleus Cytoplasm Plasma Membrane Centriolar Satellite Microtubule Plus-end Mitotic Spindle	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Protein Binding Protein Homodimerization Activity Microtubule Plus-end Binding	RNA Binding Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule Cytoskeleton Organization Spindle Organization Chromosome Segregation Cell Migration Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Epidermal Growth Factor Stimulus	Maturation Of 5.8S RRNA RRNA Processing
Pathways			Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Heschl's gyrus morphology ( 25130324) Malaria ( 31844061)	Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)
Interacting Genes		17 interacting genes: ABI2 BEX2 CHMP1B CLU HSPB1 IFT20 MAPK6 MAPRE1 MAPRE3 MPHOSPH6 NUPR1 OIP5 PALS2 PPL SGF29 WASHC3 ZDHHC17	32 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		90417	10200
HPRD ID		12669	16111
Ensembl ID		ENSG00000128944	ENSG00000135698
Uniprot IDs		Q9Y448	H3BNT4 Q99547
PDB IDs			6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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