BMERB1 and RAPGEF4

Data Source:
BioGRID (two hybrid, two hybrid)

		BMERB1	RAPGEF4
Description		bMERB domain containing 1	Rap guanine nucleotide exchange factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microtubule Cytoskeleton	Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Microtubule Depolymerization Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Catalytic Activity Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle
Pathways			Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Creutzfeldt-Jakob disease (sporadic) ( 32949544)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)
Interacting Genes		3 interacting genes: ENO2 RAPGEF4 TCF12	13 interacting genes: ATXN1 BMERB1 DEF6 LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A
Entrez ID		89927	11069
HPRD ID		12382	06929
Ensembl ID		ENSG00000166780	ENSG00000091428
Uniprot IDs		A0A024QZI8 Q96MC5	B7Z278 Q8WZA2
PDB IDs
Enriched GO Terms of Interacting Partners?
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