RAPGEF4 and BMERB1

Data Source:
BioGRID (two hybrid, two hybrid)

		RAPGEF4	BMERB1
Description		Rap guanine nucleotide exchange factor 4	bMERB domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse	Microtubule Cytoskeleton
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Small GTPase Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Catalytic Activity Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle	Negative Regulation Of Microtubule Depolymerization Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)	Creutzfeldt-Jakob disease (sporadic) ( 32949544)
Interacting Genes		13 interacting genes: ATXN1 BMERB1 DEF6 LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A	3 interacting genes: ENO2 RAPGEF4 TCF12
Entrez ID		11069	89927
HPRD ID		06929	12382
Ensembl ID		ENSG00000091428	ENSG00000166780
Uniprot IDs		B7Z278 Q8WZA2	A0A024QZI8 Q96MC5
PDB IDs
Enriched GO Terms of Interacting Partners?
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