RAPGEF4 and RIMS2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RAPGEF4	RIMS2
Description		Rap guanine nucleotide exchange factor 4	regulating synaptic membrane exocytosis 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse	Presynaptic Membrane Cell Projection Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Small GTPase Binding	Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Catalytic Activity Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Cell Differentiation Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)	Cocaine dependence ( 23958962) Dietary fat liking ( 32516399) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High density lipoprotein cholesterol levels ( 30498476) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple system atrophy (pathologically confirmed) ( 27629089)
Interacting Genes		13 interacting genes: ATXN1 BMERB1 DEF6 LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A	12 interacting genes: ABCA1 CACNA1S RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH
Entrez ID		11069	9699
HPRD ID		06929	09436
Ensembl ID		ENSG00000091428	ENSG00000176406
Uniprot IDs		B7Z278 Q8WZA2	Q9UQ26
PDB IDs			1V27 1WFG
Enriched GO Terms of Interacting Partners?
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