RAPGEF4 and TSPOAP1

Data Source:
BioGRID (two hybrid)

		RAPGEF4	TSPOAP1
Description		Rap guanine nucleotide exchange factor 4	TSPO associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse	Cytoplasm Mitochondrion Cytosol Calyx Of Held Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Small GTPase Binding	Protein Binding Benzodiazepine Receptor Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Catalytic Activity Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle	C21-steroid Hormone Biosynthetic Process Neurotransmitter Secretion Neuromuscular Synaptic Transmission Biological_process Glutamate Secretion Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Pregnenolone biosynthesis Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)
Interacting Genes		13 interacting genes: ATXN1 BMERB1 DEF6 LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A	19 interacting genes: ANKRD11 ARNT2 BEND5 CACNA1A CADPS2 CEP76 DISC1 DLGAP2 DLX2 GPRASP2 KHDRBS1 KIF1A MVP NDE1 RAPGEF4 REL TCF4 TSC22D4 TSPO
Entrez ID		11069	9256
HPRD ID		06929	09832
Ensembl ID		ENSG00000091428	ENSG00000005379
Uniprot IDs		B7Z278 Q8WZA2	A7E2C5 B2RUT8 B7ZVZ7 O95153 X5DQQ3
PDB IDs
Enriched GO Terms of Interacting Partners?
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