ATP6V0E1 and APOD

Data Source:
BioGRID (two hybrid)

		ATP6V0E1	APOD
Description		ATPase H+ transporting V0 subunit e1	apolipoprotein D
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Hydrolase Activity ATPase-coupled Ion Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism	Lipid Transporter Activity Protein Binding Cholesterol Binding
	Biological Process	Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Response To Drug Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs		Tiludronic acid	Vitamin A Copper
Diseases
GWAS		Body mass index ( 27455349) PR interval ( 32439900)	HDL cholesterol levels ( 32203549)
Interacting Genes		19 interacting genes: - APOD ATP6V1E1 CDIPT COL8A2 CXCL16 EMP1 GPR25 KIR2DL3 MAL2 MS4A13 MS4A4A NAT8 OPRM1 PLN SYT15 TMEM218 TMEM254 YIPF6	51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35C2 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR
Entrez ID		8992	347
HPRD ID		04894	00134
Ensembl ID		ENSG00000113732	ENSG00000189058
Uniprot IDs		O15342	P05090
PDB IDs			2APD 2HZQ 2HZR
Enriched GO Terms of Interacting Partners?
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