P4HA2 and CD86

Data Source:
HPRD (in vitro)

		P4HA2	CD86
Description		prolyl 4-hydroxylase subunit alpha 2	CD86 molecule
Image
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Intracellular Membrane-bounded Organelle	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Centriolar Satellite Extracellular Exosome
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Electron Transport Chain	Adaptive Immune Response Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway CD40 Signaling Pathway T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity
Pathways		Collagen biosynthesis and modifying enzymes	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Proline	Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Giant cell arteritis ( 28041642) Height ( 28552196) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 33199917) Intraocular pressure ( 29617998) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)	Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		6 interacting genes: CLNK CREB3 FHL3 P4HB PRRC2A TNS4	6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		8974	942
HPRD ID		11862	03011
Ensembl ID		ENSG00000072682	ENSG00000114013
Uniprot IDs		O15460 Q05DA4	A0A0X9R4E0 A8K632 P42081
PDB IDs		6EVL 6EVM 6EVN 6EVO 6EVP	1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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