CD86 and MARCHF8

Data Source:
HPRD (in vitro, in vivo)

		CD86	MARCHF8
Description		CD86 molecule	membrane associated ring-CH-type finger 8
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Centriolar Satellite Extracellular Exosome	Cytoplasm Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding MHC Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway CD40 Signaling Pathway T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity	Protein Polyubiquitination Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1	11 interacting genes: ARR3 CD86 CYB5B FA2H GOSR2 IL1RAP TMEM14C UBE2D1 UBE2D3 UBE2H VAMP2
Entrez ID		942	220972
HPRD ID		03011	17466
Ensembl ID		ENSG00000114013	ENSG00000165406
Uniprot IDs		A0A0X9R4E0 A8K632 P42081	A0A024R7U2 Q5T0T0
PDB IDs		1I85 1NCN 5YXK	2D8S
Enriched GO Terms of Interacting Partners?
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