P4HA2 and TNS4

Data Source:
BioGRID (two hybrid)

		P4HA2	TNS4
Description		prolyl 4-hydroxylase subunit alpha 2	tensin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Intracellular Membrane-bounded Organelle	Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding	Actin Binding Protein Binding
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Electron Transport Chain	Apoptotic Process Protein Localization
Pathways		Collagen biosynthesis and modifying enzymes	MET interacts with TNS proteins
Drugs		Proline
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Giant cell arteritis ( 28041642) Height ( 28552196) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 33199917) Intraocular pressure ( 29617998) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)	Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		6 interacting genes: CLNK CREB3 FHL3 P4HB PRRC2A TNS4	25 interacting genes: AR CARD9 CBL CYSRT1 EGFR ERBB3 ERBB4 GAB1 GSTCD HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 PPP3CA RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1
Entrez ID		8974	84951
HPRD ID		11862	12223
Ensembl ID		ENSG00000072682	ENSG00000131746
Uniprot IDs		O15460 Q05DA4	Q6PJP3 Q8IZW8
PDB IDs		6EVL 6EVM 6EVN 6EVO 6EVP
Enriched GO Terms of Interacting Partners?
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