TNS4 and P4HA2

Data Source:
BioGRID (two hybrid)

		TNS4	P4HA2
Description		tensin 4	prolyl 4-hydroxylase subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Focal Adhesion	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Actin Binding Protein Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding
	Biological Process	Apoptotic Process Protein Localization	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Electron Transport Chain
Pathways		MET interacts with TNS proteins	Collagen biosynthesis and modifying enzymes
Drugs			Proline
Diseases
GWAS		Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Giant cell arteritis ( 28041642) Height ( 28552196) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 33199917) Intraocular pressure ( 29617998) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		25 interacting genes: AR CARD9 CBL CYSRT1 EGFR ERBB3 ERBB4 GAB1 GSTCD HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 PPP3CA RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1	6 interacting genes: CLNK CREB3 FHL3 P4HB PRRC2A TNS4
Entrez ID		84951	8974
HPRD ID		12223	11862
Ensembl ID		ENSG00000131746	ENSG00000072682
Uniprot IDs		Q6PJP3 Q8IZW8	O15460 Q05DA4
PDB IDs			6EVL 6EVM 6EVN 6EVO 6EVP
Enriched GO Terms of Interacting Partners?
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