TAX1BP1 and ORC5

Data Source:
BioGRID (two hybrid)

		TAX1BP1	ORC5
Description		Tax1 binding protein 1	origin recognition complex subunit 5
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	Protein Binding Kinase Binding Metal Ion Binding	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Negative Regulation Of Apoptotic Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication
Pathways		Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)	Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		75 interacting genes: ARHGAP1 AZI2 C18orf25 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN EMILIN1 FAM161A FAM168A FAM189A2 FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LGALS8 LITAF LMO3 LNX1 LRATD2 MAP1LC3B MAP1LC3C MRPL11 MRPL53 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RB1CC1 RIPK1 RNF11 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP1 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446	30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2
Entrez ID		8887	5001
HPRD ID		05618	09086
Ensembl ID		ENSG00000106052	ENSG00000164815
Uniprot IDs		B4DSG5 Q86VP1	A4D0P7 O43913 Q53FC8
PDB IDs		2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G	5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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