ORC5 and DMRTA1

Data Source:
BioGRID (two hybrid)

		ORC5	DMRTA1
Description		origin recognition complex subunit 5	DMRT like family A1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Chromatin Nucleus
	Molecular Function	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication	Ovarian Follicle Development Regulation Of Transcription By RNA Polymerase II Germ Cell Development Sex Differentiation Male Mating Behavior
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)	Adventurousness ( 30643258) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Atopic dermatitis ( 25865352) Blood sugar levels ( 29403010) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Chronic lymphocytic leukemia ( 26956414) Dentures ( 31235808) General risk tolerance (MTAG) ( 30643258) Glucose homeostasis traits ( 25524916) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) Hypertension ( 30487518) Lymphocyte counts ( 29403010) Metabolite levels ( 23823483) Monocyte count ( 29403010) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Pulse pressure ( 27841878) Systolic blood pressure ( 30224653) Tuberculosis ( 24057671) Type 2 diabetes ( 26818947 30718926) White blood cell count ( 29403010)
Interacting Genes		30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2	2 interacting genes: ORC5 STAT5B
Entrez ID		5001	63951
HPRD ID		09086	10913
Ensembl ID		ENSG00000164815	ENSG00000176399
Uniprot IDs		A4D0P7 O43913 Q53FC8	Q5VZB9
PDB IDs		5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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