ORC5 and ORC1

Data Source:
HPRD (in vitro)

		ORC5	ORC1
Description		origin recognition complex subunit 5	origin recognition complex subunit 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding	DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding ATPase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Mitotic DNA Replication Checkpoint
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2	23 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RPA2 SKP2 XPO1
Entrez ID		5001	4998
HPRD ID		09086	03544
Ensembl ID		ENSG00000164815	ENSG00000085840
Uniprot IDs		A4D0P7 O43913 Q53FC8	B7Z8H0 Q13415 Q96F82
PDB IDs		5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS	5UJ7 5UJM 6P3W 7JPO 7JPP 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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