TAX1BP1 and DSTN

Data Source:
BioGRID (two hybrid, two hybrid)

		TAX1BP1	DSTN
Description		Tax1 binding protein 1	destrin, actin depolymerizing factor
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cytoplasm Actin Cytoskeleton Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Kinase Binding Metal Ion Binding	Protein Binding Actin Filament Binding
	Biological Process	Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Negative Regulation Of Apoptotic Process	Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Cell Motility Actin Filament Severing
Pathways		Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs			Dodecyldimethylamine N-oxide
Diseases
GWAS		Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)	Coronary artery disease ( 29212778) Presence of antiphospholipid antibodies ( 23509613)
Interacting Genes		75 interacting genes: ARHGAP1 AZI2 C18orf25 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN EMILIN1 FAM161A FAM168A FAM189A2 FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LGALS8 LITAF LMO3 LNX1 LRATD2 MAP1LC3B MAP1LC3C MRPL11 MRPL53 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RB1CC1 RIPK1 RNF11 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP1 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446	8 interacting genes: ACTB ACTG1 CFL2 SHBG SMAD9 SSH1 TAX1BP1 TESK2
Entrez ID		8887	11034
HPRD ID		05618	16446
Ensembl ID		ENSG00000106052	ENSG00000125868
Uniprot IDs		B4DSG5 Q86VP1	P60981 V9HWA6
PDB IDs		2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G
Enriched GO Terms of Interacting Partners?
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