GARS1 and NAE1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GARS1	NAE1
Description		glycyl-tRNA synthetase 1	NEDD8 activating enzyme E1 subunit 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Axon Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Protein Dimerization Activity	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation	Signal Transduction Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation Neuron Apoptotic Process
Pathways		Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Neddylation
Drugs		Glycine	ATP
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		11 interacting genes: CD44 CELSR2 DUX4 EEF1D HSPB2 IARS1 LINC01554 MAP3K10 MAPK8 NAE1 NEDD8	10 interacting genes: ALG8 APP GARS1 NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4
Entrez ID		2617	8883
HPRD ID		02617	04545
Ensembl ID		ENSG00000106105	ENSG00000159593
Uniprot IDs		A0A090N8G0 A0A6Q8PGW4 P41250	Q13564
PDB IDs		2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?
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