ARHGEF7 and PPM1F

Data Source:
HPRD (in vivo)

		ARHGEF7	PPM1F
Description		Rho guanine nucleotide exchange factor 7	protein phosphatase, Mg2+/Mn2+ dependent 1F
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Neuron Projection Neuronal Cell Body	Nucleus Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Golgi Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of GTP Binding Positive Regulation Of Lamellipodium Morphogenesis	Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Histone Dephosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Growth Positive Regulation Of Chemotaxis Negative Regulation Of Protein Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Peptidyl-serine Dephosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		EGFR downregulation NRAGE signals death through JNK Rho GTPase cycle Ephrin signaling G alpha (12/13) signalling events	Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756)
Interacting Genes		33 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG	19 interacting genes: AATK ARHGEF7 CAMK2A ERBB2 ERBB3 ERBB4 FAM161A FEM1A FEM1B KLHL8 LATS1 LMTK2 MARS1 MEOX1 PAK1 PRKAA1 PTK7 ROR1 ROR2
Entrez ID		8874	9647
HPRD ID		05688	10163
Ensembl ID		ENSG00000102606	ENSG00000100034
Uniprot IDs		A0A024RDY9 B7Z344 B7Z6G2 E9PDQ5 Q14155 Q5W9H1	B5MCT7 P49593
PDB IDs		1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?
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