ARHGEF7 and SCRIB

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ARHGEF7	SCRIB
Description		Rho guanine nucleotide exchange factor 7	scribble planar cell polarity protein
Image
GO Annotations	Cellular Component	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Neuron Projection Neuronal Cell Body	Immunological Synapse Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Lamellipodium Cell Junction Cell Leading Edge Scrib-APC-beta-catenin Complex Presynaptic Membrane Postsynaptic Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding	Protein Binding Cadherin Binding
	Biological Process	Golgi Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of GTP Binding Positive Regulation Of Lamellipodium Morphogenesis	Establishment Of T Cell Polarity Neural Tube Closure Positive Regulation Of Receptor Recycling Cell Population Proliferation Embryo Development Cell Migration Mitigation Of Host Immune Response By Virus Polarized Epithelial Cell Differentiation Positive Regulation Of Interferon-gamma Production Establishment Of Apical/basal Cell Polarity Suppression By Virus Of Host STAT1 Activity Suppression By Virus Of Host STAT2 Activity Positive Regulation Of Apoptotic Process Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Activated T Cell Proliferation Positive Chemotaxis Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction Activation Of GTPase Activity Receptor Localization To Synapse Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome
Pathways		EGFR downregulation NRAGE signals death through JNK Rho GTPase cycle Ephrin signaling G alpha (12/13) signalling events	Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824)	Menarche (age at onset) ( 25231870)
Interacting Genes		33 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG	12 interacting genes: APC ARHGEF7 C5AR2 EXOSC10 LPP MAPK3 PRKCA STX4 TJP2 TRIP6 TSHR UBE3A
Entrez ID		8874	23513
HPRD ID		05688	06984
Ensembl ID		ENSG00000102606	ENSG00000180900
Uniprot IDs		A0A024RDY9 B7Z344 B7Z6G2 E9PDQ5 Q14155 Q5W9H1	A0A0G2JNZ2 A0A0G2JPP5 A0PJK8 Q14160
PDB IDs		1BY1 1ZSG 2L3G 5SXP	1UJU 1WHA 1X5Q 2W4F 4WYT 4WYU 5VWC 5VWI 5VWK 6EEY 6ESP 6MS1 6MTU 6MTV 6MYE 6MYF
Enriched GO Terms of Interacting Partners?
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