PPM1F and ROR2

Data Source:
BioGRID (two hybrid)

		PPM1F	ROR2
Description		protein phosphatase, Mg2+/Mn2+ dependent 1F	receptor tyrosine kinase like orphan receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm	Microtubule Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Histone Dephosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Growth Positive Regulation Of Chemotaxis Negative Regulation Of Protein Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Peptidyl-serine Dephosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Smoothened Signaling Pathway JNK Cascade Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Cell Migration BMP Signaling Pathway Embryonic Genitalia Morphogenesis Male Genitalia Development Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Cell Fate Commitment Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Synaptic Transmission, Glutamatergic Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Kinase C Activity Macrophage Migration
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission	PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases			Brachydactyly, including: type A; type B; type D; type E Robinow syndrome
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)
Interacting Genes		19 interacting genes: AATK ARHGEF7 CAMK2A ERBB2 ERBB3 ERBB4 FAM161A FEM1A FEM1B KLHL8 LATS1 LMTK2 MARS1 MEOX1 PAK1 PRKAA1 PTK7 ROR1 ROR2	74 interacting genes: ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C19orf54 C1orf94 C3orf56 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MSX2 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34
Entrez ID		9647	4920
HPRD ID		10163	03822
Ensembl ID		ENSG00000100034	ENSG00000169071
Uniprot IDs		B5MCT7 P49593	Q01974
PDB IDs			3ZZW 4GT4 6OSH 6OSN 6OSV
Enriched GO Terms of Interacting Partners?
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