ARHGEF7 and NCKIPSD

Data Source:
HPRD (in vivo, in vitro)

		ARHGEF7	NCKIPSD
Description		Rho guanine nucleotide exchange factor 7	NCK interacting protein with SH3 domain
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GO Annotations	Cellular Component	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Neuron Projection Neuronal Cell Body	Cytosol Intermediate Filament COP9 Signalosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding
	Biological Process	Golgi Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of GTP Binding Positive Regulation Of Lamellipodium Morphogenesis	Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways		EGFR downregulation NRAGE signals death through JNK Rho GTPase cycle Ephrin signaling G alpha (12/13) signalling events	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824)	Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		33 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG	41 interacting genes: ABI2 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GAS7 GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C
Entrez ID		8874	51517
HPRD ID		05688	09450
Ensembl ID		ENSG00000102606	ENSG00000213672
Uniprot IDs		A0A024RDY9 B7Z344 B7Z6G2 E9PDQ5 Q14155 Q5W9H1	Q9NZQ3
PDB IDs		1BY1 1ZSG 2L3G 5SXP	6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?
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