CD84 and SH2D1A

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CD84	SH2D1A
Description		CD84 molecule	SH2 domain containing 1A
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Autophagy Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Mast Cell Activation Negative Regulation Of Mast Cell Degranulation Innate Immune Response Leukocyte Migration Regulation Of Store-operated Calcium Entry	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Cell surface interactions at the vascular wall	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Response to anti-TNF therapy in rheumatoid arthritis ( 23555300)
Interacting Genes		2 interacting genes: SH2D1A SH2D1B	32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		8832	4068
HPRD ID		05151	02390
Ensembl ID		ENSG00000066294	ENSG00000183918
Uniprot IDs		Q9UIB8	O60880
PDB IDs		2PKD	1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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