CD84 and SH2D1B

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		CD84	SH2D1B
Description		CD84 molecule	SH2 domain containing 1B
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle	Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Adaptive Immune Response Autophagy Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Mast Cell Activation Negative Regulation Of Mast Cell Degranulation Innate Immune Response Leukocyte Migration Regulation Of Store-operated Calcium Entry	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Immune Response
Pathways		Cell surface interactions at the vascular wall	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Response to anti-TNF therapy in rheumatoid arthritis ( 23555300)	Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)
Interacting Genes		2 interacting genes: SH2D1A SH2D1B	25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54
Entrez ID		8832	117157
HPRD ID		05151	12248
Ensembl ID		ENSG00000066294	ENSG00000198574
Uniprot IDs		Q9UIB8	O14796
PDB IDs		2PKD	5KAZ
Enriched GO Terms of Interacting Partners?
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