SH2D1A and SLAMF1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SH2D1A	SLAMF1
Description		SH2 domain containing 1A	signaling lymphocytic activation molecule family member 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding SH2 Domain Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway	Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Phagocytosis Cell Adhesion Positive Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of JNK Cascade Lymphocyte Activation Viral Entry Into Host Cell Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Memory decline ( 31985465) Microalbuminuria ( 26631737) Multiple sclerosis ( 31604244) Schizophrenia (treatment resistant) ( 22479419)
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	6 interacting genes: FGR FYN INPP5D PTPN11 SH2D1A SH2D1B
Entrez ID		4068	6504
HPRD ID		02390	04603
Ensembl ID		ENSG00000183918	ENSG00000117090
Uniprot IDs		O60880	Q13291
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	1D4T 1D4W 1I3Z 1KA6 1KA7 1M27 2DZF 2IE9 2IFL 2IG5
Enriched GO Terms of Interacting Partners?
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