SH2D1A and CD84

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SH2D1A	CD84
Description		SH2 domain containing 1A	CD84 molecule
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway	Adaptive Immune Response Autophagy Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Mast Cell Activation Negative Regulation Of Mast Cell Degranulation Innate Immune Response Leukocyte Migration Regulation Of Store-operated Calcium Entry
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cell surface interactions at the vascular wall
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Response to anti-TNF therapy in rheumatoid arthritis ( 23555300)
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	2 interacting genes: SH2D1A SH2D1B
Entrez ID		4068	8832
HPRD ID		02390	05151
Ensembl ID		ENSG00000183918	ENSG00000066294
Uniprot IDs		O60880	Q9UIB8
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	2PKD
Enriched GO Terms of Interacting Partners?
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