TNFRSF6B and PPP1R7

Data Source:
BioGRID (two hybrid)

		TNFRSF6B	PPP1R7
Description		TNF receptor superfamily member 6b	protein phosphatase 1 regulatory subunit 7
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Chromosome Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity
	Biological Process	Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879 23727859) Blood protein levels ( 30072576 29875488) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Glioma ( 22886559) Inflammatory bowel disease ( 18758464 28067908 23128233) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		6 interacting genes: FASLG KRTAP10-3 KRTAP10-9 PPP1R7 TNFSF14 TNFSF15	12 interacting genes: CLNK FER HGS MAPK6 MYH3 PPP1CA PPP1CB PPP1CC SPRED1 TAB1 TNFRSF6B USHBP1
Entrez ID		8771	5510
HPRD ID		04527	04192
Ensembl ID		ENSG00000243509	ENSG00000115685
Uniprot IDs		O95407	A0A140VK83 Q15435
PDB IDs		3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSV 5L36	6HKW 6MKY 6OBN 6OBP
Enriched GO Terms of Interacting Partners?
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