TNFRSF6B and TNFSF15

Data Source:
HPRD (in vivo)

		TNFRSF6B	TNFSF15
Description		TNF receptor superfamily member 6b	TNF superfamily member 15
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS	Crohn's disease
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879 23727859) Blood protein levels ( 30072576 29875488) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Glioma ( 22886559) Inflammatory bowel disease ( 18758464 28067908 23128233) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633)	Asthma ( 32296059) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 21102463 32581322 26891255 23266558) Inflammatory bowel disease ( 27569725 18758464 23128233) Leprosy ( 20018961 25642632) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483 23000144 28062665 30643196) Ulcerative colitis ( 20848476 21297633) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		6 interacting genes: FASLG KRTAP10-3 KRTAP10-9 PPP1R7 TNFSF14 TNFSF15	2 interacting genes: TNFRSF25 TNFRSF6B
Entrez ID		8771	9966
HPRD ID		04527	04956
Ensembl ID		ENSG00000243509	ENSG00000181634
Uniprot IDs		O95407	A0A0U5JA19 O95150
PDB IDs		3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSV 5L36	2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?
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