PPP1R7 and TNFRSF6B

Data Source:
BioGRID (two hybrid)

		PPP1R7	TNFRSF6B
Description		protein phosphatase 1 regulatory subunit 7	TNF receptor superfamily member 6b
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity	Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879 23727859) Blood protein levels ( 30072576 29875488) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Glioma ( 22886559) Inflammatory bowel disease ( 18758464 28067908 23128233) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		12 interacting genes: CLNK FER HGS MAPK6 MYH3 PPP1CA PPP1CB PPP1CC SPRED1 TAB1 TNFRSF6B USHBP1	6 interacting genes: FASLG KRTAP10-3 KRTAP10-9 PPP1R7 TNFSF14 TNFSF15
Entrez ID		5510	8771
HPRD ID		04192	04527
Ensembl ID		ENSG00000115685	ENSG00000243509
Uniprot IDs		A0A140VK83 Q15435	O95407
PDB IDs		6HKW 6MKY 6OBN 6OBP	3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSV 5L36
Enriched GO Terms of Interacting Partners?
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