TNFSF13 and TNFRSF17

Data Source:
HPRD (in vitro)

		TNFSF13	TNFRSF17
Description		TNF superfamily member 13	TNF receptor superfamily member 17
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Plasma Membrane Endomembrane System Integral Component Of Membrane
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding Receptor Ligand Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Isotype Switching To IgA Isotypes	Adaptive Immune Response Lymphocyte Homeostasis Signal Transduction Multicellular Organism Development Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs			Belantamab mafodotin
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 22864923 28628107) IgA nephropathy ( 26028593 25305756 22197929) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 22558069 29403010) Serum total protein level ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Blood protein levels ( 30072576) Phenylephrine infusion rate during anesthesia ( 31455332) QT interval ( 19305408) Testicular germ cell tumor ( 26503584)
Interacting Genes		13 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 SGTB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B	8 interacting genes: CMTM7 PEX16 TMBIM6 TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3
Entrez ID		8741	608
HPRD ID		05128	00144
Ensembl ID		ENSG00000161955	ENSG00000048462
Uniprot IDs		B3KR02 O75888 Q2QBA2	Q02223
PDB IDs		4ZCH	1OQD 1XU2 2KN1 4ZFO 6J7W
Enriched GO Terms of Interacting Partners?
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