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SERPINH1 and CDK9
Data Source:
HPRD
(in vitro)
SERPINH1
CDK9
Description
serpin family H member 1
cyclin dependent kinase 9
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Membrane Raft
Collagen-containing Extracellular Matrix
Nucleus
Nucleoplasm
Transcription Elongation Factor Complex
Cyclin/CDK Positive Transcription Elongation Factor Complex
Membrane
Mediator Complex
PML Body
Cytoplasmic Ribonucleoprotein Granule
P-TEFb Complex
Molecular Function
RNA Binding
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Collagen Binding
Unfolded Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Protein Kinase Binding
7SK SnRNA Binding
Biological Process
Chondrocyte Development Involved In Endochondral Bone Morphogenesis
Response To Unfolded Protein
Negative Regulation Of Endopeptidase Activity
Collagen Fibril Organization
Collagen Biosynthetic Process
Protein Maturation
DNA Repair
Regulation Of DNA Repair
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
Protein Phosphorylation
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Positive Regulation Of Cardiac Muscle Hypertrophy
Regulation Of Histone Modification
Replication Fork Processing
Positive Regulation Of Histone Phosphorylation
Response To Drug
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Muscle Cell Differentiation
Phosphorylation Of RNA Polymerase II C-terminal Domain
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Cytokine Stimulus
Negative Regulation Of MRNA Polyadenylation
Positive Regulation Of MRNA 3'-UTR Binding
Positive Regulation Of Histone H2B Ubiquitination
Pathways
Collagen biosynthesis and modifying enzymes
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression
Drugs
Alvocidib
Seliciclib
Diseases
GWAS
Coronary artery disease (
29212778
33020668
)
Height (
28552196
20881960
22021425
25282103
25429064
31562340
28270201
)
Hip circumference adjusted for BMI (
25673412
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for body mass index (
28448500
)
Body mass index (
26426971
)
Interacting Genes
18 interacting genes:
BAG6
BRCA2
C1QL3
CD9
CDK9
CEP70
COL26A1
ESR2
FEZ1
H1-5
KLF13
LINC01554
NSG2
PPARG
SLC2A4
SLC35F6
UBQLN4
UBTF
58 interacting genes:
ACTL6A
AFF4
AR
BCL10
CASK
CCNK
CCNT1
CCNT2
CDC34
CDC7
CDK5R1
CDK7
CEBPB
CTDP1
CTDSPL
CUL1
DHX30
EEF1D
FBXO25
GRN
GTF2F1
H2BC21
HEXIM1
HEXIM2
HLTF
HSPA1A
HTATSF1
IL6ST
LBX2
MBP
MDFIC
MED21
MYBL2
MYC
NBN
NFKB1
NR2E3
PIN1
POLR2A
RB1
RCHY1
RELA
RMND5B
RN7SK
SERPINH1
SKP1
SKP2
SMAD1
SMAD2
SMAD3
STAT3
STK36
SUPT5H
TAF7
TP53
TRAF2
UBE2A
ZMYM6
Entrez ID
871
1025
HPRD ID
02968
16016
Ensembl ID
ENSG00000149257
ENSG00000136807
Uniprot IDs
A0A024R5K8
A8K259
P50454
A0A024R880
P50750
PDB IDs
1PF6
3BLH
3BLQ
3BLR
3LQ5
3MI9
3MIA
3MY1
3TN8
3TNH
3TNI
4BCF
4BCG
4BCH
4BCI
4BCJ
4EC8
4EC9
4IMY
4OGR
4OR5
5L1Z
6CYT
6GZH
Enriched GO Terms of Interacting Partners
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