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CDK9 and MED21
Data Source:
HPRD
(in vivo, in vitro)
CDK9
MED21
Description
cyclin dependent kinase 9
mediator complex subunit 21
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Elongation Factor Complex
Cyclin/CDK Positive Transcription Elongation Factor Complex
Membrane
Mediator Complex
PML Body
Cytoplasmic Ribonucleoprotein Granule
P-TEFb Complex
Mediator Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Protein Kinase Binding
7SK SnRNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Biological Process
DNA Repair
Regulation Of DNA Repair
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
Protein Phosphorylation
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Positive Regulation Of Cardiac Muscle Hypertrophy
Regulation Of Histone Modification
Replication Fork Processing
Positive Regulation Of Histone Phosphorylation
Response To Drug
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Muscle Cell Differentiation
Phosphorylation Of RNA Polymerase II C-terminal Domain
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Cytokine Stimulus
Negative Regulation Of MRNA Polyadenylation
Positive Regulation Of MRNA 3'-UTR Binding
Positive Regulation Of Histone H2B Ubiquitination
Regulation Of Transcription By RNA Polymerase II
RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Drugs
Alvocidib
Seliciclib
Diseases
GWAS
Body mass index (
26426971
)
Dimensional psychopathology (Social) (
29496196
)
Interacting Genes
58 interacting genes:
ACTL6A
AFF4
AR
BCL10
CASK
CCNK
CCNT1
CCNT2
CDC34
CDC7
CDK5R1
CDK7
CEBPB
CTDP1
CTDSPL
CUL1
DHX30
EEF1D
FBXO25
GRN
GTF2F1
H2BC21
HEXIM1
HEXIM2
HLTF
HSPA1A
HTATSF1
IL6ST
LBX2
MBP
MDFIC
MED21
MYBL2
MYC
NBN
NFKB1
NR2E3
PIN1
POLR2A
RB1
RCHY1
RELA
RMND5B
RN7SK
SERPINH1
SKP1
SKP2
SMAD1
SMAD2
SMAD3
STAT3
STK36
SUPT5H
TAF7
TP53
TRAF2
UBE2A
ZMYM6
30 interacting genes:
BLOC1S6
BORCS6
BRCA1
BTF3
CDK8
CDK9
ELOA
ESR1
ESR2
HGS
HNF4A
HTT
MAGEA6
MAGEB4
MED29
MIEF1
PCBD2
POLR2A
SKP1
SSC5D
TARBP2
TFG
THRA
THRB
TP53
TRIM27
TRIM72
VAV2
ZNF655
ZSCAN1
Entrez ID
1025
9412
HPRD ID
16016
09156
Ensembl ID
ENSG00000136807
ENSG00000152944
Uniprot IDs
A0A024R880
P50750
A0A024RAW0
Q13503
PDB IDs
1PF6
3BLH
3BLQ
3BLR
3LQ5
3MI9
3MIA
3MY1
3TN8
3TNH
3TNI
4BCF
4BCG
4BCH
4BCI
4BCJ
4EC8
4EC9
4IMY
4OGR
4OR5
5L1Z
6CYT
6GZH
Enriched GO Terms of Interacting Partners
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