CDK9 and HSPA1A

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		CDK9	HSPA1A
Description		cyclin dependent kinase 9	heat shock protein family A (Hsp70) member 1A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Membrane Mediator Complex PML Body Cytoplasmic Ribonucleoprotein Granule P-TEFb Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Protein Kinase Binding 7SK SnRNA Binding	Virus Receptor Activity G Protein-coupled Receptor Binding Transcription Corepressor Activity RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Denatured Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Protein Folding Chaperone Cadherin Binding Protein N-terminus Binding Unfolded Protein Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Disordered Domain Specific Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Regulation Of Mitotic Cell Cycle Cell Population Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Histone Modification Replication Fork Processing Positive Regulation Of Histone Phosphorylation Response To Drug SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Muscle Cell Differentiation Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus Negative Regulation Of MRNA Polyadenylation Positive Regulation Of MRNA 3'-UTR Binding Positive Regulation Of Histone H2B Ubiquitination	MRNA Catabolic Process Response To Unfolded Protein Lysosomal Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Cell Death Vesicle-mediated Transport Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Neutrophil Degranulation Regulation Of MRNA Stability Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Viral Entry Into Host Cell Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Negative Regulation Of Cell Death Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endoribonuclease Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Neutrophil degranulation
Drugs		Alvocidib Seliciclib
Diseases
GWAS		Body mass index ( 26426971)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Schizophrenia ( 30285260) Ulcerative colitis ( 28067908)
Interacting Genes		58 interacting genes: ACTL6A AFF4 AR BCL10 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CDK7 CEBPB CTDP1 CTDSPL CUL1 DHX30 EEF1D FBXO25 GRN GTF2F1 H2BC21 HEXIM1 HEXIM2 HLTF HSPA1A HTATSF1 IL6ST LBX2 MBP MDFIC MED21 MYBL2 MYC NBN NFKB1 NR2E3 PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 SUPT5H TAF7 TP53 TRAF2 UBE2A ZMYM6	88 interacting genes: AIFM1 AIMP2 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAAF4 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 EGFR EIF2AK2 ERBB2 ERBB3 FANCC FOS GPR37 GRIN1 GRIN2D HAP1 HCFC1 HEMGN HIVEP1 HMGA1 HSBP1 HSF1 HSPA8 HSPBP1 IKBKG INS KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PGR PLG POT1 PPP1R15A PRKCA PSMC5 PTGES3 PTMA PTPRF RAP1A RAPGEF2 RHOA SAE1 SLC13A1 SLC5A1 SNCB SNRK SOX9 ST13 STIP1 STUB1 SUMO2 TCERG1 TGM2 TOMM70 TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 XIAP YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		1025	3303
HPRD ID		16016	00774
Ensembl ID		ENSG00000136807	ENSG00000204389
Uniprot IDs		A0A024R880 P50750	A8K5I0 B3KTT5 P0DMV8 P0DMV9
PDB IDs		1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH	1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39
Enriched GO Terms of Interacting Partners?
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