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CDK9 and CDC7
Data Source:
BioGRID
(two hybrid)
CDK9
CDC7
Description
cyclin dependent kinase 9
cell division cycle 7
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Elongation Factor Complex
Cyclin/CDK Positive Transcription Elongation Factor Complex
Membrane
Mediator Complex
PML Body
Cytoplasmic Ribonucleoprotein Granule
P-TEFb Complex
Nucleus
Nucleoplasm
Cytoplasm
Intercellular Bridge
Mitotic Spindle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Protein Kinase Binding
7SK SnRNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
DNA Repair
Regulation Of DNA Repair
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
Protein Phosphorylation
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Positive Regulation Of Cardiac Muscle Hypertrophy
Regulation Of Histone Modification
Replication Fork Processing
Positive Regulation Of Histone Phosphorylation
Response To Drug
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Muscle Cell Differentiation
Phosphorylation Of RNA Polymerase II C-terminal Domain
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Cytokine Stimulus
Negative Regulation Of MRNA Polyadenylation
Positive Regulation Of MRNA 3'-UTR Binding
Positive Regulation Of Histone H2B Ubiquitination
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Break-induced Replication
DNA Replication
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Nuclear Cell Cycle DNA Replication
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Peptidyl-serine Phosphorylation
Cell Cycle Phase Transition
Cell Division
Negative Regulation Of G0 To G1 Transition
Pathways
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Transcriptional Regulation by E2F6
Drugs
Alvocidib
Seliciclib
Diseases
GWAS
Body mass index (
26426971
)
Eosinophil percentage of white cells (
27863252
)
Gestational age at birth (maternal effect) (
28877031
)
Glaucoma (primary open-angle) (
25861811
)
Lung function (FEV1/FVC) (
28166213
)
Lung function (FVC) (
26635082
)
Optic disc area (
25631615
31798171
28073927
21307088
)
Optic disc parameters (
20548946
)
Optic disc size (
31809533
)
Optic nerve measurement (cup-to-disc ratio) (
28061514
)
Plateletcrit (
32888494
)
PR interval (
32439900
)
Response to fenofibrate (HDL cholesterol levels) (
27002377
)
Vertical cup-disc ratio (
31798171
25241763
28073927
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
58 interacting genes:
ACTL6A
AFF4
AR
BCL10
CASK
CCNK
CCNT1
CCNT2
CDC34
CDC7
CDK5R1
CDK7
CEBPB
CTDP1
CTDSPL
CUL1
DHX30
EEF1D
FBXO25
GRN
GTF2F1
H2BC21
HEXIM1
HEXIM2
HLTF
HSPA1A
HTATSF1
IL6ST
LBX2
MBP
MDFIC
MED21
MYBL2
MYC
NBN
NFKB1
NR2E3
PIN1
POLR2A
RB1
RCHY1
RELA
RMND5B
RN7SK
SERPINH1
SKP1
SKP2
SMAD1
SMAD2
SMAD3
STAT3
STK36
SUPT5H
TAF7
TP53
TRAF2
UBE2A
ZMYM6
52 interacting genes:
APP
BANP
CALCOCO2
CDK2
CDK4
CDK9
CDKN1A
CDKN2A
CHAF1A
CLSPN
DBF4
DBF4B
DIAPH1
DTD1
FXR1
GMEB2
GOLGA2
GOLGA6A
GPT
GRHPR
HMBOX1
HOMEZ
IKZF1
IKZF3
IKZF4
LZTS1
MCM10
MCM2
MCM3
MCM4
MCM5
MCM6
MCM7
MEOX2
MTUS2
NDUFB2
ORC1
ORC5
ORC6
PGK1
SERTAD2
STAM2
TMBIM6
TOB1
TRIM27
TRIM37
TSNAXIP1
TSPY10
TSPY3
ZBTB10
ZBTB26
ZBTB8B
Entrez ID
1025
8317
HPRD ID
16016
10345
Ensembl ID
ENSG00000136807
ENSG00000097046
Uniprot IDs
A0A024R880
P50750
A0A384MTU6
B2R6V2
O00311
PDB IDs
1PF6
3BLH
3BLQ
3BLR
3LQ5
3MI9
3MIA
3MY1
3TN8
3TNH
3TNI
4BCF
4BCG
4BCH
4BCI
4BCJ
4EC8
4EC9
4IMY
4OGR
4OR5
5L1Z
6CYT
6GZH
4F99
4F9A
4F9B
4F9C
5UWQ
5UWR
6YA6
6YA7
6YA8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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