DGAT1 and CCR9

Data Source:
BioGRID (two hybrid)

		DGAT1	CCR9
Description		diacylglycerol O-acyltransferase 1	C-C motif chemokine receptor 9
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Specific Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	2-acylglycerol O-acyltransferase Activity Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity, Transferring Acyl Groups Identical Protein Binding Retinol O-fatty-acyltransferase Activity	Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Monoacylglycerol Biosynthetic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Lipid Storage Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Neutrophil Degranulation Diacylglycerol Metabolic Process Fatty Acid Homeostasis	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Acyl chain remodeling of DAG and TAG Neutrophil degranulation Triglyceride biosynthesis	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Vercirnon
Diseases
GWAS		Dupuytren's disease ( 28886342)	Celiac disease ( 20190752) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		3 interacting genes: CCR9 CD1A GABRA4	19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE
Entrez ID		8694	10803
HPRD ID		05360	09200
Ensembl ID		ENSG00000185000	ENSG00000173585
Uniprot IDs		O75907	B2R734 P51686
PDB IDs		6VP0 6VYI 6VZ1	5LWE
Enriched GO Terms of Interacting Partners?
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