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EPHA2 and HGF
Data Source:
BioGRID
(fluorescent resonance energy transfer)
EPHA2
HGF
Description
EPH receptor A2
hepatocyte growth factor
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Lamellipodium
Leading Edge Membrane
Lamellipodium Membrane
Ruffle Membrane
Neuron Projection
Receptor Complex
Tight Junction
Extracellular Region
Extracellular Space
Membrane
Platelet Alpha Granule Lumen
Molecular Function
Virus Receptor Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane-ephrin Receptor Activity
Protein Binding
ATP Binding
Cadherin Binding
Serine-type Endopeptidase Activity
Protein Binding
Growth Factor Activity
Chemoattractant Activity
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Skeletal System Development
Vasculogenesis
Osteoblast Differentiation
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Lamellipodium Assembly
Notochord Formation
Cell Migration
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Neural Tube Development
Keratinocyte Differentiation
Osteoclast Differentiation
Negative Regulation Of Chemokine Production
Mammary Gland Epithelial Cell Proliferation
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Kinase Activity
Post-anal Tail Morphogenesis
Protein Kinase B Signaling
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Angiogenesis
CAMP Metabolic Process
Viral Entry Into Host Cell
Bone Remodeling
Ephrin Receptor Signaling Pathway
Axial Mesoderm Formation
Cell Motility
Defense Response To Gram-positive Bacterium
Negative Regulation Of Protein Kinase B Signaling
Notochord Cell Development
Cell Chemotaxis
Branching Involved In Mammary Gland Duct Morphogenesis
Lens Fiber Cell Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Response To Growth Factor
Protein Localization To Plasma Membrane
Activation Of GTPase Activity
Negative Regulation Of Lymphangiogenesis
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Bicellular Tight Junction Assembly
Pericyte Cell Differentiation
MAPK Cascade
Activation Of MAPK Activity
Mitotic Cell Cycle
Cell Morphogenesis
Epithelial To Mesenchymal Transition
Liver Development
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Proteolysis
Negative Regulation Of Autophagy
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cytokine-mediated Signaling Pathway
Hyaluronan Metabolic Process
Positive Regulation Of Cell Migration
Animal Organ Regeneration
Positive Regulation Of Myelination
Negative Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-10 Production
Negative Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Hepatocyte Growth Factor Stimulus
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Myoblast Proliferation
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Positive Regulation Of Neuron Projection Regeneration
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of P38MAPK Cascade
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Tau-protein Kinase Activity
Positive Regulation Of DNA Biosynthetic Process
Pathways
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
Platelet degranulation
PIP3 activates AKT signaling
Interleukin-7 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
Drugs
Dasatinib
Phosphoaminophosphonic Acid-Adenylate Ester
Regorafenib
Fostamatinib
Heparin
O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
ABT-510
Foretinib
Diseases
GWAS
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Blood protein levels (
30072576
29875488
)
Endothelial growth factor levels (
25552591
)
Gestational age at birth (maternal effect) (
28598419
)
Gout (
22179738
)
Gout (normal type) (
32238385
)
Hepatocyte growth factor levels (
27989323
25998175
)
Intraocular pressure (
29785010
29235454
)
Rosacea symptom severity (
29771307
)
Spontaneous preterm birth (maternal effect) (
28598419
)
Transverse temporal cortex volume (
31530798
)
Tuberculosis (
29036319
)
Interacting Genes
84 interacting genes:
ABCB5
ACP1
AKT1
APP
ARAF
ARNT
AURKA
BECN1
CBL
CBLC
CCND2
CD44
CDC42
CDH5
CDK17
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CLDN4
DUSP14
DUSP18
DUSP19
DUSP26
DUSP29
EFNA1
EFNA2
EFNA3
EFNA4
EFNA5
EGFR
ERBB2
FGFR4
FZR1
GATAD1
GLIS2
GRB2
GRK2
GRM1
HGF
HIF1A
ILKAP
KDELR2
KPNA3
LATS2
LSM7
MAP2K5
MAP2K6
MAPK14
MDM4
MET
MSH2
MYC
NF1
NF2
NFIC
NUDT9
PDGFRA
PIK3R1
PIK3R2
PPM1L
PSME2
PTEN
PTK2
PTPN11
PTPN7
PTPRR
RAF1
RASA1
RASSF1
RBL1
RELA
SHC1
SLA
STK11
STYX
TEAD2
TIAM1
TNFAIP1
TP53
TPTE
TPTE2
UBE4A
37 interacting genes:
ADAMTSL4
ARNT
BRCA1
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
CLEC3B
EPHA2
ERBB2
F11
FGFR4
FN1
GLIS2
HGFAC
HPN
KLKB1
LATS2
LCN2
MAP2K5
MAP2K6
MDM4
MEOX2
MET
MYC
NF2
PDGFRA
PLAU
RAF1
SDC1
SDC2
ST14
STK11
TEAD2
VTN
YWHAG
Entrez ID
1969
3082
HPRD ID
01494
00799
Ensembl ID
ENSG00000142627
ENSG00000019991
Uniprot IDs
A0A024QZA8
P29317
P14210
PDB IDs
1MQB
2E8N
2K9Y
2KSO
2X10
2X11
3C8X
3CZU
3FL7
3HEI
3HPN
3KKA
3MBW
3MX0
3SKJ
4P2K
4PDO
4TRL
5EK7
5I9U
5I9V
5I9W
5I9X
5I9Y
5I9Z
5IA0
5IA1
5IA2
5IA3
5IA4
5IA5
5NJZ
5NK0
5NK1
5NK2
5NK3
5NK4
5NK5
5NK6
5NK7
5NK8
5NK9
5NKA
5NKB
5NKC
5NKD
5NKE
5NKF
5NKG
5NKH
5NKI
5NZ9
6B9L
6F7M
6F7N
6FNF
6FNG
6FNH
6HES
6HET
6HEU
6HEV
6HEW
6HEX
6HEY
6NJZ
6NK0
6NK1
6NK2
6NKP
6Q7B
6Q7C
6Q7D
6Q7E
6Q7F
6Q7G
6RW2
7CZE
7CZF
1BHT
1GMN
1GMO
1GP9
1NK1
1SHY
1SI5
2HGF
2QJ2
3HMS
3HMT
3HN4
3MKP
3SP8
4D3C
4K3J
4O3T
4O3U
5COE
5CP9
5CS1
5CS3
5CS5
5CS9
5CSQ
5CT1
5CT2
5CT3
Enriched GO Terms of Interacting Partners
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