FRS2 and RND1

Data Source:
HPRD (in vitro)

		FRS2	RND1
Description		fibroblast growth factor receptor substrate 2	Rho family GTPase 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Endomembrane System Membrane	Cytosol Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phosphatase Activator Activity	GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Gastrulation With Mouth Forming Second Organ Induction Ventricular Septum Development Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuroblast Proliferation Axon Guidance Fibroblast Growth Factor Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Development Regulation Of Apoptotic Process Optic Placode Formation Involved In Camera-type Eye Formation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cardiac Muscle Cell Differentiation	Actin Filament Organization Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Neuron Remodeling Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		PI3K Cascade PIP3 activates AKT signaling Frs2-mediated activation Frs2-mediated activation Constitutive Signaling by Aberrant PI3K in Cancer PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Complete remission in asthma ( 29786918) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Logical memory (delayed recall) in normal cognition ( 29274321) Microalbuminuria ( 31511532) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Thyroid stimulating hormone levels ( 32769997) Urinary albumin-to-creatinine ratio ( 31511532)	Bipolar disorder ( 21926972)
Interacting Genes		28 interacting genes: BECN1 CBL CDK3 CRK DDR1 FGFR1 GAB1 GRB2 INSR KDR MAPK1 MAPK3 NCK1 NTRK1 NTRK2 NTRK3 PAK1 PIN1 PRKCI PRKCZ PTPN11 PTPRF RET RND1 RPS6 SOS1 SRC YJU2	23 interacting genes: ARFIP2 ARHGAP5 CCNI COPS2 CREB3L2 EEF1A1 FRS2 FRS3 GPX8 GRB7 ID3 MYH7 MYOM3 MYZAP NEDD1 PAIP1 PDE6D PLXNA1 PLXNB1 PLXNB2 RAI14 UBXN11 ZNF212
Entrez ID		10818	27289
HPRD ID		06372	12357
Ensembl ID		ENSG00000166225	ENSG00000172602
Uniprot IDs		L7RTG7 Q8WU20	Q92730
PDB IDs		1XR0 2MFQ	2CLS 2REX 3Q3J
Enriched GO Terms of Interacting Partners?
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