DYNLL1 and ERG28

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DYNLL1	ERG28
Description		dynein light chain LC8-type 1	ergosterol biosynthesis 28 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium COP9 Signalosome Membrane Dynein Complex Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Transport Vesicle
	Molecular Function	Motor Activity Enzyme Inhibitor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding	Molecular_function Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Spermatid Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Neutrophil Degranulation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	Biological_process Sterol Biosynthetic Process
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		107 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C12orf40 C14orf119 C19orf44 CA2 CACNB1 CCDC28A CLIP2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNAL4 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 EEF1A1 ERG28 FAM117B FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 ODF3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710	124 interacting genes: ALDH2 ANXA1 ANXA7 AQP2 AQP3 AQP6 BAIAP2 BCL2L13 BID BTBD2 CCDC106 CCL18 CD53 CD74 CDC42 CDK5RAP2 CELF3 CLDN5 CLDN7 CLN8 COX17 CRADD CREB1 CREB3 CREB3L1 CSTF2 CYB561 DYNLL1 EBP ELOVL4 ERBB2 ERBB3 ERBB4 FAM174A FAM209A FAS FCGR2B FFAR2 FXR1 FXYD3 GADD45A GET1 GJB5 GPR152 GPR37L1 GPX8 GSK3B HMGB1 HNRNPH3 HNRNPUL1 HSD17B11 HSPE1 HTR2C HYLS1 JAGN1 KCNJ6 KLHL20 LHFPL5 LMNA LSM2 LYPD5 MAPK8IP2 MFSD14B MGST3 MPHOSPH6 MRM1 MRPL38 MRPS12 MS4A3 MSMO1 MTERF3 MTNR1B MUC1 NAT9 NCR3LG1 NDUFA3 NDUFA4L2 NR1H2 NSF PAFAH1B3 PCDHA4 PDZK1IP1 PEX2 PFN1 PHYHIP PIGY POLE2 POLR2C POLR3F PPP1R8 PQBP1 PSCA RAB27A REEP4 RETREG3 RPS6KA6 S100A8 SAR1A SAT1 SCN3B SEPHS1 SERPINB9 SGPL1 SLC10A6 SLC26A6 SLC34A2 SNRPB SNRPG SSMEM1 STOM STX1A SULT1E1 TFG TK1 TLCD4 TM4SF19 TMEM106A TMEM222 TMEM31 TMPRSS2 TSC22D1 TTR ZFP64 ZNF24
Entrez ID		8655	11161
HPRD ID		03334	05201
Ensembl ID		ENSG00000088986	ENSG00000133935
Uniprot IDs		P63167 Q6FGH9	Q6FII3 Q86TW5 Q9UKR5
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2
Enriched GO Terms of Interacting Partners?
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