TCAP and KLHL41

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TCAP	KLHL41
Description		titin-cap	kelch like family member 41
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Z Disc I Band	Ruffle Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Pseudopodium M Band Cul3-RING Ubiquitin Ligase Complex Sarcoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Ion Channel Binding FATZ Binding Titin Z Domain Binding	Protein Binding
	Biological Process	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Cardiac Muscle Fiber Development Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Protein-containing Complex Assembly	Striated Muscle Contraction Protein Ubiquitination Myofibril Assembly Regulation Of Lateral Pseudopodium Assembly Skeletal Muscle Cell Differentiation Post-translational Protein Modification Sarcomere Organization Regulation Of Myoblast Differentiation Skeletal Muscle Fiber Development Regulation Of Myoblast Proliferation Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Striated Muscle Contraction	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD)
GWAS		Alcohol consumption ( 31358974) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)
Interacting Genes		38 interacting genes: ADPGK ANKRD2 ASB6 ATXN1 BLZF1 C19orf54 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN HSPA8 HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN	9 interacting genes: C4orf45 IFRD1 MYBPC1 NRAP POMP RBM4 RCHY1 SLC2A4 TCAP
Entrez ID		8557	10324
HPRD ID		05133	07610
Ensembl ID		ENSG00000173991	ENSG00000239474
Uniprot IDs		A2TDC0 O15273	O60662
PDB IDs		1YA5 2F8V
Enriched GO Terms of Interacting Partners?
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