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TCAP and MSTN
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
TCAP
MSTN
Description
titin-cap
myostatin
Image
GO Annotations
Cellular Component
Cytosol
Z Disc
I Band
Extracellular Space
Cytoplasm
Molecular Function
Protein Binding
Structural Constituent Of Muscle
Protein-macromolecule Adaptor Activity
Titin Binding
BMP Binding
Ion Channel Binding
FATZ Binding
Titin Z Domain Binding
Signaling Receptor Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Heparin Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Somitogenesis
Skeletal Muscle Contraction
Cardiac Muscle Hypertrophy
Adult Heart Development
Cardiac Muscle Hypertrophy In Response To Stress
Muscle Filament Sliding
Skeletal Muscle Thin Filament Assembly
Skeletal Muscle Myosin Thick Filament Assembly
Otic Vesicle Formation
Response To Muscle Stretch
Detection Of Muscle Stretch
Sarcomere Organization
Cardiac Muscle Fiber Development
Sarcomerogenesis
Detection Of Mechanical Stimulus
Cardiac Myofibril Assembly
Cardiac Muscle Tissue Morphogenesis
Cardiac Muscle Contraction
Protein-containing Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Muscle Organ Development
Response To Heat
Response To Gravity
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Skeletal Muscle Atrophy
Negative Regulation Of Muscle Hypertrophy
Myoblast Migration Involved In Skeletal Muscle Regeneration
Response To Muscle Activity
Ovulation Cycle Process
Response To Testosterone
Negative Regulation Of Kinase Activity
Response To Estrogen
Response To Ethanol
Negative Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Insulin Receptor Signaling Pathway
Muscle Cell Cellular Homeostasis
Negative Regulation Of Skeletal Muscle Tissue Growth
Response To Electrical Stimulus
Negative Regulation Of Protein Kinase B Signaling
SMAD Protein Signal Transduction
Cellular Response To Dexamethasone Stimulus
Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation
Negative Regulation Of Satellite Cell Differentiation
Negative Regulation Of Myoblast Proliferation
Pathways
Striated Muscle Contraction
FOXO-mediated transcription of cell cycle genes
Drugs
MYO-029
Diseases
Limb-girdle muscular dystrophy (LGMD)
GWAS
Alcohol consumption (
31358974
)
Asthma (
31959851
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Pancreatic ductal adenocarcinoma (
30541042
)
Refractive error (
32231278
)
Ulcerative colitis (
20228799
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
38 interacting genes:
ADPGK
ANKRD2
ASB6
ATXN1
BLZF1
C19orf54
CDCA4
CHORDC1
CRK
ENO1
ENO3
FAM153B
FAS
FYN
HSPA8
HSPB2
HSPB3
HSPG2
IKZF3
KLHL41
KRTAP19-7
LAMTOR5
LHX4
MDM2
MSTN
MYOZ1
MYOZ3
NUP133
PAX7
PDPK1
RELA
SAPCD1
SIVA1
TRIM54
TRIM55
TRIM63
TTC19
TTN
6 interacting genes:
ACVR2B
APP
FSTL3
SGTA
TCAP
WFIKKN2
Entrez ID
8557
2660
HPRD ID
05133
03474
Ensembl ID
ENSG00000173991
ENSG00000138379
Uniprot IDs
A2TDC0
O15273
O14793
Q53S46
PDB IDs
1YA5
2F8V
5F3B
5F3H
5NTU
5NXS
6UMX
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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