MICALL1 and RFFL

Data Source:
BioGRID (enzymatic study)

		MICALL1	RFFL
Description		MICAL like 1	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Early Endosome Late Endosome Trans-Golgi Network Extrinsic Component Of Membrane Late Endosome Membrane Recycling Endosome Membrane	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding Phosphatidic Acid Binding	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Neuron Projection Development Slow Endocytic Recycling Protein Localization To Endosome Plasma Membrane Tubulation Retrograde Transport, Endosome To Plasma Membrane	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways			Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		8 interacting genes: EHD1 EHD3 RAB13 RAB1A RFFL YWHAB YWHAG ZP3	21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		85377	117584
HPRD ID		11363	11489
Ensembl ID		ENSG00000100139	ENSG00000092871
Uniprot IDs		Q8N3F8	Q8WZ73
PDB IDs		2KSP	1Y02
Enriched GO Terms of Interacting Partners?
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