ALG2 and PTPN23

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ALG2	PTPN23
Description		ALG2 alpha-1,3/1,6-mannosyltransferase	protein tyrosine phosphatase non-receptor type 23
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Actin Cytoskeleton Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Nuclear Body Ciliary Basal Body Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man1GlcNAc2-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding GDP-Man:Man2GlcNAc2-PP-dolichol Alpha-1,6-mannosyltransferase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein Glycosylation In Endoplasmic Reticulum Response To Calcium Ion Mannosylation	Negative Regulation Of Epithelial Cell Migration Protein Transport Endocytic Recycling Peptidyl-tyrosine Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Early Endosome To Late Endosome Transport Cilium Assembly Positive Regulation Of Wnt Protein Secretion Cellular Response To Cytokine Stimulus Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG2 causes ALG2-CDG (CDG-1i)	Interleukin-37 signaling
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031)	C-reactive protein levels ( 30388399) Refractive error ( 32231278) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		4 interacting genes: ANXA11 PEF1 PTPN23 SRI	11 interacting genes: ALG2 CEP19 CEP55 CHMP4B DDX24 LRRK2 NOTCH2NLA PSMA3 TRIM27 UBAP1 UBC
Entrez ID		85365	25930
HPRD ID		09716	05959
Ensembl ID		ENSG00000119523	ENSG00000076201
Uniprot IDs		A0A024R184 Q9H553	B4DST5 Q9H3S7
PDB IDs			3RAU 5CRU 5CRV 5LM1 5LM2 5MJY 5MJZ 5MK0 5MK1 5MK2 5MK3
Enriched GO Terms of Interacting Partners?
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