ALG2 and SRI

Data Source:
BioGRID (pull down)

		ALG2	SRI
Description		ALG2 alpha-1,3/1,6-mannosyltransferase	sorcin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Actin Cytoskeleton Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Exosome
	Molecular Function	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man1GlcNAc2-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding GDP-Man:Man2GlcNAc2-PP-dolichol Alpha-1,6-mannosyltransferase Activity	Protease Binding Signaling Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein Glycosylation In Endoplasmic Reticulum Response To Calcium Ion Mannosylation	Action Potential Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG2 causes ALG2-CDG (CDG-1i)	Stimuli-sensing channels Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Ion transport by P-type ATPases
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		4 interacting genes: ANXA11 PEF1 PTPN23 SRI	20 interacting genes: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA MTNR1A NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12 USHBP1
Entrez ID		85365	6717
HPRD ID		09716	01680
Ensembl ID		ENSG00000119523	ENSG00000075142
Uniprot IDs		A0A024R184 Q9H553	B4DHQ6 C9J0K6 P30626
PDB IDs			1JUO 2JC2 4U8D 4UPG 4USL 5MRA
Enriched GO Terms of Interacting Partners?
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