JAK3 and PTPRC

Data Source:
HPRD (in vitro)

		JAK3	PTPRC
Description		Janus kinase 3	protein tyrosine phosphatase receptor type C
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GO Annotations	Cellular Component	Endosome Cytosol Cytoskeleton Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Secretory Granule Membrane Bleb Membrane Raft Extracellular Exosome Membrane Microdomain
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Protein Kinase Binding Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	MAPK Cascade Adaptive Immune Response Negative Regulation Of Dendritic Cell Cytokine Production Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway B Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of FasL Production Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9	Activation Of MAPK Activity Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Viral Process Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Autophosphorylation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Neutrophil Degranulation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Tyrosine Phosphatase Activity Negative Regulation Of Microglial Cell Activation DN2 Thymocyte Differentiation Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling Potential therapeutics for SARS	Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one R-348 Tofacitinib Baricitinib Fostamatinib Zanubrutinib
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Apolipoprotein B levels ( 32203549) Asthma ( 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 26192919 28067908) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 20139978 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966) Ulcerative colitis ( 24837172) Vitiligo ( 27723757) White blood cell count ( 32888494)
Interacting Genes		42 interacting genes: ALK APOA1 CD247 CD40 CD81 CDK1 CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK LNX1 PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B TIAF1 UHRF2 VIL1	45 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 ZAP70
Entrez ID		3718	5788
HPRD ID		02547	01050
Ensembl ID		ENSG00000105639	ENSG00000081237
Uniprot IDs		A0A024R7M7 P52333	M9MML4 P08575
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ 5TTS 5TTU 5TTV 5VO6 5W86 5WFJ 6AAK 6DA4 6DB3 6DB4 6DUD 6GL9 6GLA 6GLB 6HZV 6NY4 7C3N	1YGR 1YGU 5FMV 5FN6 5FN7
Enriched GO Terms of Interacting Partners?
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