PCGF1 and UBE2U

Data Source:
BioGRID (two hybrid)

		PCGF1	UBE2U
Description		polycomb group ring finger 1	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	HULC Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Metal Ion Binding Promoter-specific Chromatin Binding	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Regulation Of Transcription, DNA-templated Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Severe bacterial meningitis ( 31092817)
Interacting Genes		12 interacting genes: BCOR CALCOCO2 CBX6 CBX7 FCHO1 MUC7 PCGF5 RNF125 RNF2 TRIM55 UBE2D3 UBE2U	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		84759	148581
HPRD ID		11404	14599
Ensembl ID		ENSG00000115289	ENSG00000177414
Uniprot IDs		Q9BSM1	A0A140VJY9 Q5VVX9
PDB IDs		4HPL 4HPM 5JH5	1YRV
Enriched GO Terms of Interacting Partners?
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