SORBS2 and VCL

Data Source:
HPRD (in vitro)

		SORBS2	VCL
Description		sorbin and SH3 domain containing 2	vinculin
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Actin Cytoskeleton Apical Plasma Membrane Z Disc Lamellipodium Perinuclear Region Of Cytoplasm	Podosome Extracellular Region Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Costamere Cell-cell Contact Zone Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Actin Filament Organization Notch Signaling Pathway Biological_process Cell Growth Involved In Cardiac Muscle Cell Development	Morphogenesis Of An Epithelium Platelet Degranulation Muscle Contraction Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Apical Junction Assembly Neutrophil Degranulation Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Adherens Junction
Pathways			Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) Short-term memory (digit-span task) ( 30741946) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Cardiac troponin-I levels ( 31014085) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular internal dimension in diastole ( 29403010) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)
Interacting Genes		45 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ	38 interacting genes: ABI2 ACTA1 ACTN1 BCAR1 BIRC6 BRME1 CDH1 CLTC CORO2B CTNNA1 ENOX2 GSN ITGA5 LINC01554 LPXN NEBL NRAP PKD1 POMP PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SAPCD2 SELE SORBS1 SORBS2 SORBS3 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP
Entrez ID		8470	7414
HPRD ID		12473	01900
Ensembl ID		ENSG00000154556	ENSG00000035403
Uniprot IDs		B7Z3D7 B7Z997 O94875	A0A024QZN4 B3KXA2 P18206 V9HWK2
PDB IDs		5VEI	1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY 6UPW
Enriched GO Terms of Interacting Partners?
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