SORBS2 and AFDN

Data Source:
HPRD (in vitro)

		SORBS2	AFDN
Description		sorbin and SH3 domain containing 2	afadin, adherens junction formation factor
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Actin Cytoskeleton Apical Plasma Membrane Z Disc Lamellipodium Perinuclear Region Of Cytoplasm	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction
	Molecular Function	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Notch Signaling Pathway Biological_process Cell Growth Involved In Cardiac Muscle Cell Development	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Adherens Junction Organization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) Short-term memory (digit-span task) ( 30741946) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		45 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ	37 interacting genes: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		8470	4301
HPRD ID		12473	01164
Ensembl ID		ENSG00000154556	ENSG00000130396
Uniprot IDs		B7Z3D7 B7Z997 O94875	A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		5VEI	1T2M 1XZ9 2AIN 2EXG 5A6C
Enriched GO Terms of Interacting Partners?
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