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TRIM55 and RELA
Data Source:
BioGRID
(two hybrid)
TRIM55
RELA
Description
tripartite motif containing 55
RELA proto-oncogene, NF-kB subunit
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Microtubule
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
NF-kappaB P50/p65 Complex
Glutamatergic Synapse
Molecular Function
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Protein Kinase Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Peptide Binding
Phosphate Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Protein N-terminus Binding
NF-kappaB Binding
Repressing Transcription Factor Binding
Ankyrin Repeat Binding
Biological Process
Leukocyte Migration Involved In Inflammatory Response
Signal Transduction
Protein Ubiquitination
Diapedesis
Macrophage Migration
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Hair Follicle Development
Stimulatory C-type Lectin Receptor Signaling Pathway
Acetaldehyde Metabolic Process
Chromatin Organization
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Aging
Positive Regulation Of Cell Population Proliferation
Animal Organ Morphogenesis
Response To Organic Substance
Response To UV-B
Positive Regulation Of Schwann Cell Differentiation
Viral Process
Cytokine-mediated Signaling Pathway
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Type I Interferon Production
Response To Muramyl Dipeptide
Response To Progesterone
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-8 Production
Response To Insulin
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Protein Sumoylation
Cellular Response To Stress
Response To Cobalamin
Response To Cytokine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Response To Muscle Stretch
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Protein Catabolic Process
Response To Drug
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Response To Morphine
Regulation Of DNA-templated Transcription In Response To Stress
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Inflammatory Response
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To CAMP
Defense Response To Virus
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Postsynapse To Nucleus Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Positive Regulation Of Amyloid-beta Formation
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Cellular Response To Angiotensin
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of MiRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Purinergic signaling in leishmaniasis infection
Drugs
Dimethyl fumarate
SC-236
Diseases
GWAS
Coronary heart disease event reduction (statin therapy interaction) (
22666496
)
Metabolite levels (
23823483
)
Recurrent major depressive disorder (
29317602
)
Acne (severe) (
24927181
)
Asthma (
31619474
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol levels (
32203549
)
Sensation seeking (
30718321
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Urate levels (
31985003
31578528
)
Interacting Genes
310 interacting genes:
ACBD4
ACD
ACTA1
ADAMTSL4
AEBP2
AFM
AGO2
AKR1C8P
ALKBH3
ANKRD1
ANKRD39
APLN
APOBEC4
ARL6IP4
ATG4D
ATP5F1B
ATP5F1D
ATXN3
ATXN3L
ATXN7L1
BCAT1
BCHE
BRAP
BRD4
BRWD1
BTBD9
BYSL
C10orf88
C12orf4
C1orf35
C3orf36
C8orf74
CADPS
CAMK2A
CAPN3
CARS1
CBX2
CCDC120
CCDC130
CCDC28B
CDK3
CDS2
CENPK
CHMP7
CKM
COA7
COX4I1
CRCT1
CTAG1A
CTAG1B
CTNNB1
CTSF
CYB5R2
CYP46A1
CYTOR
DAPL1
DCAF11
DCAF6
DCTN3
DECR2
DEF8
DEK
DES
DNTTIP1
DOCK7
DYNLT2B
EED
EEF1G
EHHADH
EIF3E
ELAPOR1
EPS8L2
ESPL1
EZH2
FAM185A
FAM90A1
FANK1
FASTKD1
FHL2
FKBP6
FLNA
FLNB
FLNC
FRMD6
FYN
GABPB1
GATA3
GFM1
GLI4
GMEB1
GOLGA2P5
GPRIN2
GPS1
GRB10
GRB14
HID1
HIRA
HOXA1
HROB
HSPB1
ID1
IFI35
IGF2
IK
IL37
ILF3
INCA1
ING4
INKA1
IQUB
IRF2
IRF3
ITGB5
JADE3
KBTBD4
KCTD15
KIAA0087
KIAA0408
KIF13A
KIF1B
KIF5A
KLHDC4
KLHL36
KMT2B
KYAT1
LAGE3
LAMTOR5
LAPTM4A
LIMS2
LINC00518
LINC00663
LINC00905
LINC01588
LMCD1
LMO2
LRRC56
LYN
LYNX1
MAGEC3
MALSU1
MAP3K14
MBD4
MBIP
MCM7
MDM4
MIDN
MIIP
MKI67
MLH3
MLLT11
MPP1
MPZL1
MRPL19
MRPL20-AS1
MRPL41
MSRB3
MYBPC1
MYBPC3
MYBPHL
MYC
MYCT1
MYOT
MYOZ1
NDUFA1
NDUFA8
NEB
NEBL
NEFL
NGEF
NOMO1
NR1D2
NR2C2
NSD3
NSUN7
NUFIP2
ODF2
OGFOD2
OTUB1
OTUB2
P3H3
PACRGL
PAFAH1B2
PCGF1
PCGF3
PCGF6
PELI3
PELO
PHC2
PHF23
PIAS1
PIAS2
PIAS3
PIP4K2B
PKM
PLEKHG4
PLXNA3
POLD1
POLR2E
PPARA
PPIE
PRKAB2
PRKACA
PRR30
PRRT1
PYGM
RABEPK
RAD23A
RAI2
RBM14
RELA
REX1BD
RGR
RHEB
RHPN1
RING1
RNF10
RNF114
RPS4X
RRAS
RUSC1
RUSC1-AS1
SEC23B
SET
SHFL
SLC6A13
SLFN12
SNW1
SPATS1
SPRYD7
SPSB1
SPSB2
SQSTM1
STAM
SYMPK
SYNCRIP
TCAP
TCP10L
TEX19
THAP3
TIGD5
TIMM17B
TMBIM1
TMEM35A
TNIP3
TNNI1
TNNI2
TNNI3
TOR1AIP2
TPD52L3
TRAF3IP2
TRIB3
TRIM23
TRIM27
TRIM35
TRIM41
TRIM54
TRIM63
TRIM69
TRMT10B
TSC2
TSC22D4
TTN
TUBGCP4
UBA3
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2L3
UCHL3
UCHL5
UNKL
USP13
USP28
USP4
USP5
USP7
USP8
UXT
VAC14
VPS37A
WT1
XAGE1B
YOD1
YPEL3
ZBTB14
ZBTB17
ZC2HC1C
ZC3H12A
ZC3HC1
ZFYVE19
ZNF124
ZNF20
ZNF302
ZNF333
ZNF345
ZNF431
ZNF436
ZNF460
ZNF566
ZNF57
ZNF581
ZNF597
ZNF649
ZNF653
ZNF667-AS1
ZNF767P
ZNF775
ZNF83
ZSCAN16
203 interacting genes:
AATF
ACTL6A
AGO1
AHR
AKAP8
APBA2
AR
ARNT
ASB9
AURKA
BANP
BATF2
BRCA1
BRMS1
BTK
BTRC
C1QB
CALM1
CAMK4
CARM1
CCL5
CCND2
CDC34
CDK9
CEBPB
CEBPD
CHEK1
CHUK
CNNM3
COL2A1
COMMD1
CREBBP
CSNK1G1
CSNK2A1
CSNK2A2
DDC
DDX1
DHX9
DNAJA3
DNMT3L
ECSIT
EEF1D
EGR1
EP300
EPHA2
ESR1
ETHE1
EZH2
FAF1
FKBP11
FOS
FUS
GLIS1
GOPC
GTF2B
HDAC1
HDAC2
HDAC3
HEXIM1
HMGA2
HMGB1
HSPA4
IGF1R
IKBKB
IKBKE
IKBKG
ING4
IRAK1BP1
IRF1
IRF2
IRF3
IRF8
IRF9
ISL1
JUN
KAT2A
KAT2B
KAT5
KDM2A
KEAP1
KPNA2
LATS2
LMO2
MAP2K6
MAP3K7
MAP3K8
MAPK10
MAPK14
MED15
MED23
MED7
MEN1
MEOX2
MKRN2
MST1R
MTPN
MX1
MYC
NCOA3
NCOA6
NCOR2
NFIC
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NKRF
NKX2-1
NOTCH1
NPM1
NR3C1
PARP1
PDCD11
PGR
PIAS1
PIAS3
PIK3CA
PIN1
PKM
PLA2G4A
PLK1
PML
POU2F1
POU6F2
PPARA
PPARG
PPP1R13L
PPP2CA
PPP2CB
PPP2R1B
PPP4C
PRKACA
PRKCZ
PRMT1
PRTN3
PSMD10
RAD51
RASSF1
REL
RELB
REPS2
RFC1
RIOK2
RNASE1
RNF25
RPL13
RPL23
RPS3
RPS6KA5
RTN4IP1
RXRA
SAT1
SETD7
SIN3A
SIRT1
SMAD3
SMAD4
SNIP1
SNRNP70
SOCS1
SOCS6
SORD
SP1
SRF
STAT1
STAT3
STAT6
SUOX
TAF1
TAF11
TAF4B
TAF6
TAF9
TBK1
TBP
TCAP
TCF4
TERT
TGM2
TLE5
TNIP2
TP53
TP53BP1
TP53BP2
TRIB3
TRIM55
TRIM63
TRIP4
TSC22D3
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBE2L3
UNC5CL
USF2
USP7
ZBTB7A
ZBTB7B
Entrez ID
84675
5970
HPRD ID
05927
01241
Ensembl ID
ENSG00000147573
ENSG00000173039
Uniprot IDs
Q9BYV6
A0A087X0W8
Q04206
PDB IDs
1NFI
2LSP
2O61
3GUT
3QXY
3RC0
4KV1
4KV4
5U4K
5URN
6NV2
6QHL
6QHM
6YOW
6YOX
6YOY
6YP2
6YP3
6YP8
6YPL
6YPY
6YQ2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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